Ultra-Large-Scale Integration (ULSI) technology has enabled the integration of billions of transistors on a single chip, powering modern computing devices. However, as device dimensions shrink and complexity increases, reliability challenges such as wear-out mechanisms, process variations, and transient faults become critical. This paper explores the application of Artificial Intelligence (AI) models to optimize reliability in ULSI circuits. By leveraging machine learning and deep learning techniques, predictive models for failure analysis, lifetime estimation, and fault detection are developed. The results demonstrate significant improvements in reliability prediction accuracy and proactive optimization strategies, contributing to enhanced ULSI chip robustness and performance. Keywords: ULSI, Reliability Optimization, Artificial Intelligence, Machine Learning, Deep Learning, Failure Prediction, Fault Detection.